Anti-Infectives | Anti-Infectives

ESCMID guidelines for the treatment of infections caused by Gram-negative bacilli including third generation cephalosporin-resistant Enterobacterales and carbapenem-resistant Gram-negative bacteria.¹
HIS-IPS guidelines for the prevention and control of methicillin-resistant Staphylococcus aureus (MRSA) infections in healthcare settings.²
SA Health best practice guidelines for the prevention and control of vancomycin-resistant enterococci (VRE) infections in healthcare facilities.³

The IDSA (the Infectious Diseases Society of America) regularly publishes guidance with a sharp focus on fewer infections rather than generating whole new guidelines which are typically hampered by prolonged timelines.⁴ Their latest focuses on Gram-negative bacteria:

IDSA guidance on managing extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE) or Pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa) infections.⁴
IDSA guidance on treating AmpC β-lactamase-producing Enterobacterales (AmpC-E), carbapenem-resistant Acinetobacter baumannii (CRAB), and Stenotrophomonas maltophilia infections.⁵

Guidelines provide best-practice recommendations that match the fast-evolving dynamism of antibacterial resistance. Working together as antimicrobial champions around the world we'll get closer to our goal: successful stewardship with improved antibiotic use.

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AmpC-E, AmpC -lactamase-producing Enterobacterales; CRAB, carbapenem-resistant Acinetobacter baumannii; CRE, carbapenem-resistant Enterobacterales; DTR-P. aeruginosa, Pseudomonas aeruginosa with difficult-to-treat resistance; ESBL-E, extended-spectrum B-lactamase-producing Enterobacterales; ESCMID, European Society of Clinical Microbiology and Infectious Diseases; HIS-IPS, Joint Healthcare Infection Society and Infection Prevention Society; IDS, Infectious Diseases Society of America; MRSA, methicillin-resistant Staphylococcus aureus; SA, South Australia; VRE, vancomycin-resistant enterococci; WHO, World Health Organization.

References

Paul Met al. Clin Microbiol Infect 2022;28(4):521-547.

Coia JE et al. J Hosp Infect 2021;118S:S1-S39.

Government of South Australia. SA Health. Vancomycin-resistant enterococci (VRE): Infection Prevention and Control Clinical Guideline. 2020. Available at: https://rb.gy/3aza4. Accessed August 2023.

Tamma PD et al. Infectious Diseases Society of America Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0. 2022. Available at: https://www.idsociety.org/practice-guideline/amr-guidance. Accessed August 2023.

Tamma PD et al. Infectious Diseases Society of America Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0. 2022. Available at: https://www.idsociety.org/practice-guideline/amr-guidance-2.0/.Accessed August 2023.

Bacterial Infections

Bacterial basics Detection and selection Know the negative The HAP/VAP recap Dispel the MBL Pinpoint the positive Go-to guidelines

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