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About NSCLC Definition and staging of NSCLCPrevalence and incidence of NSCLCMolecular subtypes of NSCLCKnow your EGFRKnow your ALKHeading

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Prevalence and incidence of NSCLC

Around 1,600 people are diagnosed with lung cancer every year, making it one of the most common cancers in Singapore. It is also one of the leading causes of cancer-related deaths locally.1

About NSCLC

Figure 1 shows the summary of NSCLC cases in Singapore

Figure 2 shows the Ten most frequent incident cancers and cancer deaths by sex, 2018-20223

Lung cancer refers to tumors originating in the lung parenchyma or within the bronchi.1 Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, making up approximately 85% of lung cancers, and is defined as any type of epithelial lung cancer other than small cell lung cancer (SCLC).2,3

NSCLC can be further subdivided on the basis of histological features into several categories, the most common of which are adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.4 Large cell carcinoma has been defined in the past as a tumor that lacks morphologic evidence of either glandular or squamous differentiation.5 Figure 1 shows some of the more common histological subtypes of tumors found in NSCLC.3

Lung cancer refers to tumors originating in the lung parenchyma or within the bronchi.1 Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, making up approximately 85% of lung cancers, and is defined as any type of epithelial lung cancer other than small cell lung cancer (SCLC).2,3

NSCLC can be further subdivided on the basis of histological features into several categories, the most common of which are adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.4 Large cell carcinoma has been defined in the past as a tumor that lacks morphologic evidence of either glandular or squamous differentiation.5 Figure 1 shows some of the more common histological subtypes of tumors found in NSCLC.3

Definition and staging of NSCLC Learn more Molecular subtypes of NSCLC Learn more H3 (Mobile)

Abbreviations
ALK, anaplastic lymphoma kinase; BRAF, v-raf murine sarcoma viral oncogene homolog B1; EGFR, epidermal growth factor receptor; ERBB2, erb-b2 receptor tyrosine kinase 2; KRAS, Kirsten rat sarcoma viral oncogene homolog; NSCLC, non-small-cell lung cancer; NTRK1, neurotrophic tyrosine kinase 1; RET, rearranged during transfection; ROS1, c-ros oncogene 1.

ReferencesTreatments for ALK Mutation Positive  Advanced Non Small Cell Lung Cancer. Agency For Care Effectiveness. Accessed April 2025. Available from https://www.cancer.org/cancer/types/lung-cancer/about/key-statistics.html Lung Cancer Statistics – How Common Is Lung Cancer? American Cancer Society. Singapore Cancer Registry Annual Report 2022. Health Promotion Board. National Registry of Diseases Office September 2024. Accessed April 2025
PP-LOR-SGP-0190/15APR2025
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