*Includes patients that were American Indian or Alaskan Native, Native Hawaiian or Pacific Islander, or multiracial.
^†Patients were counted for each main category in an exclusive manner.
^‡Topical agents includes corticosteroids and calcineurin inhibitors.
^§Systemic agents includes mycophenolate mofetil, methotrexate, azathioprine, corticosteroids, ciclosporin and dupilumab.
^¶Data were available for 77 patients in the placebo group, 155 patients in the Cibinqo 100 mg group, and 154 patients in the Cibinqo 200 mg group.
^#Data were available for 68 patients in the placebo group, 137 patients in the Cibinqo 100 mg group, and 138 patients in the Cibinqo 200 mg group.
​​​​​​​**Assessed in patients aged 18 years; data were available for 60 patients in the placebo group, 121 patients in the Cibinqo 100 mg group, and 119 patients in the Cibinqo 200 mg group.
^††Assessed in patients aged <18 years; data were available for 16 patients in the placebo group, 32 patients in the Cibinqo 100 mg group, and 32 patients in the Cibinqo 200 mg group.
^‡‡Data were available for 77 patients in the placebo group, 153 patients in the Cibinqo 100 mg group, and 153 patients in the Cibinqo 200 mg group.

*Patients were counted once for each main category in an exclusive manner, with systemic agents, biologics and/or topical agents taking precedence over anti-inflammatory topical agents alone.

INCLUSION CRITERIA^2,3
• ≥12 years of age
• Body weight ≥40 kg
• Clinically diagnosed with chronic AD for ≥1 year, confirmed by Hanifin and Rajka criteria of AD at the screening and baseline visits. Criteria for AD diagnosis include ≥3 of the basic features of pruritus: typical morphology and distribution, including flexural lichenification or linearity in adults and facial and extensor involvement in infants and children; chronic or chronically relapsing dermatitis; and personal or family history of atopy (asthma, allergic rhinitis, atopic dermatitis); along with ≥3 of 23 minor features specified in the criteria
• Have a documented history of inadequate response to treatment with topical medications, is not medically advisable, or require systemic therapies to control their disease
• Moderate-to-severe AD defined as BSA ≥10%, IGA ≥3, EASI ≥16 and PP-NRS ≥4 at the baseline visit
EXCLUSION CRITERIA^2,3
• Active forms of other inflammatory skin diseases
• Prior treatment with any systemic JAK inhibitors
• Vaccination with, or exposure to, a live or attenuated vaccine within 6 weeks prior to the first dose
• Participation in other clinical studies involving investigational drug(s) within 8 weeks prior to study entry
• Uncontrolled, clinically significant laboratory abnormality that could affect study interpretation
• Any major psychiatric condition
• Unwillingness to discontinue current AD medications prior to the study
• Requiring treatment with prohibited medications during the study
• Medical history of thrombocytopenia, coagulopathy or platelet dysfunction, or Q wave interval abnormalities
• Presence or history of certain infections, cancers, lymphoproliferative disorders and other medical conditions at the discretion of the investigator
• Pregnant or breastfeeding women
• Women of childbearing potential who are unwilling to use contraception